Handel Animal Welfare Award 2022 to be used

Physician Michael Karl Melzer of the College of Ulm and the Würzburg Initiative 3R (WI3R), based mostly on the Fraunhofer Translational Middle Regenerative Therapies and the College of Würzburg, will obtain the Ursula M. Händel Animal Welfare Prize 2022 from the DFG . Endowed with a complete of € 80,000, the prize is now awarded for the ninth time to researchers who’ve made enhancements in animal welfare in analysis based mostly on the 3Rs precept. The three Rs stand for Change, Cut back and Refine.

Whereas Michael Karl Melzer is an early profession doctor concerned in each medical work and scientific analysis, the Würzburg Initiative 3R (WI3R) is made up of a crew of long-time scientists, specifically Dr. Antje Appelt- Menzel, Dr. Gudrun Dandekar, Dr. Florian Groeber-Becker, Dr. Christian Lotz, assistant professor Dr. Marco Metzger, Dr. Maria Steinke and Dr. Daniela Zdzieblo.

“On account of Michael Karl Melzer’s analysis findings, the usage of experimental mice might be considerably diminished and changed at completely different ranges sooner or later, significantly in most cancers analysis. His methodology is spectacular due to its simplicity and the benefit with which it may be put into observe, “stated the chairman of the DFG Senate Animal Safety and Testing Fee, Professor Brigitte Vollmar, who can also be a member of los angeles jury of the Handel Prize for Animal Welfare. “Scientists concerned within the Würzburg Initiative 3R (WI3R) have spent years concerned within the improvement of various tissue fashions to switch animal experiments to be used not solely in analysis, but additionally in trade prescribed drugs, chemical substances and cosmetics. The success of the crew is mirrored in a formidable variety of publications, patents and initiatives “.

Michael Karl Melzer impressed the jury along with his proposal to scale back the consumption of the so-called basement membrane matrix like Matrigel through the use of pork bladder, which is mostly not processed for meat manufacturing in Germany. Basement membrane matrices are used, for instance, for analysis on embryonic improvement and tumor formation. They’re produced in mice by transplanting most cancers cells. Melzer was capable of present in his research that each pancreatic organoids and pancreatic most cancers organoids can develop very nicely on the pig’s bladder. Beforehand it was essential to transplant carcinoma cells into experimental mice for this goal. Melzer primarily goals to make use of its prize cash to advance its analysis in these areas.

He studied medication on the Technical College of Munich and obtained his doctorate there in 2020. Since 2019 he has been working as a medical assistant within the Division of Urology and Pediatric Urology on the College Hospital of Ulm. Along with her medical work, she has already revealed eight articles as a postdoc, an excellent achievement given her profession stage. Melzer is at the moment researching stem cell-based programs to higher perceive the event of most cancers within the pancreas.

In its utility, the Würzburg Initiative 3R (WI3R) offered the event and utility of six in vitro fashions of the pores and skin, cornea, gut, blood mind barrier and lung barrier organs, in addition to strong tumors: these serve to implement the “alternative “Aspect of the 3R idea. The fashions are already extensively utilized in an infection and most cancers analysis, for instance, in addition to within the testing of cosmetics, dietary dietary supplements and medical merchandise similar to medication and vaccinations. With the prize cash, the crew will search to create a 3R community, provoke scientific conferences and sponsor small-scale initiatives.

For greater than ten years, the Würzburg Initiative 3R (WI3R) has been engaged on extremely complicated modeling of illness processes and testing the results of medicine in ways in which keep away from animal experiments. A standard underlying characteristic right here is the objective of mimicking the physique’s barrier features in vitro. The outcomes achieved are of excessive technical high quality and relevance for the appliance, as evidenced by a lot of publications in famend worldwide journals.

The award winner and the award successful group have been chosen from twelve nominees. The award ceremony will happen on 13 October as a part of an Animal Welfare Day organized by the College of Münster.

The Ursula M. Handel Prize for Animal Welfare was sponsored by her homonymous benefactress. Over a interval of a long time, Ursula M. Händel (1915-2011) from Düsseldorf engaged in a lot of completely different animal welfare marketing campaign actions. Amongst different issues, she based the Bonn Working Group for Animal Safety Act and was concerned in amending the Animal Safety Act. Händel offered the DFG with funds for the Animal Welfare Award based mostly on its deep dedication to animal welfare in science and analysis. Probably the most gifted analysis prize of its type in Germany is awarded each two years.

Additional info

Media contact:

DFG Press and Public Relations, tel. +49 228 885-2109, presse@dfg.de

Prize info, Ursula M. Händel and the award winners at:


Program Contact at DFG Headquarters:

Dr. Paulin Wendler, Life Sciences 1, tel. +49 228 885-3155, paulin.wendler@dfg.de

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